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Abstract: This article describes a fluorescent molecularly imprinted polymer (MIP) capable of selective fluorescent turn-on recognition of the tumor biomarker α-fetoprotein. The technique is making use of amino-modified Mn-doped ZnS quantum dots (QDs) as solid supports, 4-vinylphenylboronic acid and methyl methacrylate as the functional monomers, γ-methacryloxypropyl trimethoxysilane as the grafting agent, and α-fetoprotein as a template. A graft imprint is created on the surface of the QDs. The functional monomers are shown to play an important role in the formation of the binding sites and in preventing nonspecific protein binding. The resulting MIP-QDs display a good linear response to α-fetoprotein in the 50 ng L-1 to 10 ++g L-1 concentration range, and the limit of detection is 48 ng L-1. In our perception, the method has a wide scope in that it may be adapted to various other glycoproteins
Template and target information: protein, glycoprotein, α-fetoprotein
Author keywords: Fluorescent probe, Manganese-doped ZnS, Glycosylation, Tumor marker, High-resolution TEM, Vinylphenylboronic acid