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Abstract: A new sensitive and selective electrochemical sensor was successfully developed for the determination of valganciclovir. It is based on one-step electropolymerization of the molecularly imprinted polymer composed from 2,2'-dithiodianiline, gold nanoparticles, and valganciclovir on a glassy carbon electrode modified with carboxyl-functionalized multiwalled carbon nanotubes via cyclic voltammetry. The gold nanoparticles were introduced into the polymer composite for the development of electrical response by facilitating charge transfer. The fabrication process of the sensor was characterized by cyclic voltammetry and electrochemical impedance spectroscopy. Under the optimized condition calibration curve of the imprinted sensor has two linear concentration ranges from 1.0 to 500.0 nM and 500.0 to 2000.0 nM, with the limit of detection of 0.3 nM. The relative standard deviation (RSD) for seven parallel determination of 1.0 μM valganciclovir at optimum conditions was found to be 2.9%. The imprinted sensor has the advantages of high porous surface structure, ease of preparation, good reproducibility, good repeatability and high selectivity and sensitivity. Furthermore, the proposed method was successfully intended for the determination of valganciclovir in real samples
Template and target information: valganciclovir
Author keywords: Valganciclovir, molecularly imprinted polymer, Drug monitoring, electropolymerization, Au nanoparticles