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Reference type: Journal
Authors: Tan YG, Yin J, Liang CD, Peng H, Nie LH, Yao SZ
Article Title: A study of a new TSM bio-mimetic sensor using a molecularly imprinted polymer coating and its application for the determination of nicotine in human serum and urine.
Publication date: 2001
Journal: Bioelectrochemistry
Volume: 53
Issue: (2)
Page numbers: 141-148.
DOI: 10.1016/S0302-4598(00)00095-7
Alternative URL: https://www.researchgate.net/publication/11998464_A_study_of_a_new_TSM_bio-mimetic_sensor_using_a_molecularly_imprinted_polymer_coating_and_its_application_for_the_determination_of_nicotine_in_human_serum_and_urine

Abstract: A new bio-mimetic quartz crystal thickness-shear-mode (TSM) sensor, using an imprinted polymer coating as the sensitive material, has been fabricated and applied to the determination of nicotine (NIC) in human serum and urine. The molecularly imprinted polymer (MIP) was synthesized using NIC as the template molecule and methacrylic acid (MAA) as the functional monomer. The sensor showed high selectivity and a sensitive response to NIC in aqueous system. The linear response range of the sensor was between 5.0 x 10(-8) and 1.0 x 10(-4) M with a detection limit of 2.5 x 10(-8) M. The viscoelasticity of the coating in the air and in liquid has been studied by the impedance spectrum, The MIP sensor was stable and exhibited effective reproducibility. Satisfactory results were achieved in the detection of the real samples. (C) 2001 Elsevier Science B.V. All rights reserved
Template and target information: nicotine
Author keywords: molecularly imprinted polymer, molecular recognition, bio- mimetic sensor, thickness-shear-mode (TSM), nicotine

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