MIPdatabase
Authors: Li SW, Yang KG, Deng N, Min Y, Liu LK, Zhang LH, Zhang YK
Article Title: Thermoresponsive Epitope Surface-Imprinted Nanoparticles for Specific Capture and Release of Target Protein from Human Plasma.
Publication date: 2016
Journal: ACS Applied Materials & Interfaces
Volume: 8
Issue: (9)
Page numbers: 5747-5751.
DOI: 10.1021/acsami.5b11415
Abstract: Among various artificial antibodies, epitope imprinted polymer has been paid increasingly attention. To modulate the "adsorption and release" behavior by environment stimuli, N-isopropylacrylamide, was adopted to fabricate the thermoresponsive epitope imprinted sites. The prepared imprinted materials could adsorb 46.6 mg/g of target protein with the imprinting factor of 4.0. The template utilization efficiency could reach as high as 8.21%. More importantly, in the real sample, the materials could controllably capture the target protein from the human plasma at 45 °C and release it at 4 °C, which demonstrated the "on-demand" application potentials of such materials in the biomolecule recognition field
Template and target information: protein, epitope, human serum albumin, HSA
Author keywords: stimuli-response, molecularly imprinting, Epitope, controllable release, protein
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