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Reference type: Journal
Authors: Bhatia T, Gupta MK, Singh P, Chauhan A, Saxena PN, Mudiam MKR
Article Title: Sol-gel approach for extracting highly versatile aspirin and its metabolites using MISPE followed by GC-MS/MS analysis.
Publication date: 2016
Journal: Bioanalysis
Volume: 8
Issue: (8)
Page numbers: 795-805.
DOI: 10.4155/bio.16.28

Abstract: Aim: Aspirin is known to be a salicylate drug widely used as an analgesic, antipyretic and anti-inflammatory drug. Methodology: Sol-gel based nanosized molecularly imprinted polymer (nMIP) has been synthesized for extraction of aspirin and its metabolites in urine followed by GC-MS/MS analysis. Results: Binding affinity of nMIP and nonimprinted polymer was found to be in the range of 70-95% and 29-45%, respectively. LOD and LOQ of aspirin and its metabolites were found to be in the range of 0.63-2.4 ng/ml and 2.07-7.68 ng/ml, respectively. Conclusion: The developed method was found to be applicable for routine analysis of aspirin and its metabolites in biological samples
Template and target information: aspirin

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