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Abstract: We describe a molecularly imprinted polymer (MIP)-based fluorescent sensor fabricated through an organogelation process. The sensor was comprised of a molecularly imprinted nanofiber as a receptor and a CdSe/ZnS quantum dot (QD) as a signal transducer. The sensor fabrication was carried out in three steps: (1) organogelation of a polymerizable gelator (PG) in the presence of the QD and a template, (2) gel-state polymerization and (3) extraction of the template. We chose histamine as a model template. PG had two different polymerizable groups: an acrylate and a diacetylene. As a functional monomer for complexation with the template, an acrylate having a carboxyl group was used. The QD and template-containing organogel formed in n-decane were polymerized in the presence of a photoinitiator and a cross-linker by UV irradiation to produce highly cross-linked organogel nanofibers. The template molecules were removed by extraction with methanol/acetic acid (9:1 v/v) to give the QD-incorporated, histamine imprinted organogel nanofibers (QD-HIOGNF). QD-HIOGNF showed high molecular recognition properties toward histamine in respects to both sensitivity and selectivity. The fluorescence intensity of QD-HIOGNF was quenched sensitively as the concentration of histamine increased. QD-HIOGNF could be reused for sensing after removing the bound analytes
Template and target information: histamine
Author keywords: Organogelation, Quantum dots, fluorescent sensor, Molecularly imprinted polymers, Organogel nanofibers, histamine