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Abstract: The effect of functional monomer on chiral separation ability of the non - covalent molecular imprinted chiral stationary phase was investigated systematically. It was found that there was compatibleness between the functional monomer and the template molecules. Strong hydrogen bond and ionic interaction could be formed between the amide group and carboxyl group in the amino acid derivatives and acrylamide and 2 vinylpyridine, which made the imprinting effect of the combined functional monomers AM + 2 - VP more evident. The competing solvent acetic acid showed great influence on the non - covalent interaction between the analyte and the functional groups of molecular imprinted polymer (MIP). Ionic interaction and hydrogen bending between amide group and carboxyl group in the analyte and the functional groups of MIP were weakened by increasing the concentration of the competing solvent acetic acid, therefore both the capacity factor, chiral selectivity faster and resolution decreased
Template and target information: N-Cbz-L-Tyr, N-Cbz-L-Phe, N-Cbz-L-Trp