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Abstract: In this paper, we reported an effective method for the preparation of molecularly imprinted polymers (MIPs) on silica gel with diethylstilbestrol (DES) as template molecule through surface-initiated atom transfer radical polymerization (ATRP). A novel stir bar sorptive extraction (SBSE) coating was prepared based on MIPs by glass filling with magnetic core as substrate through sol-gel. The structure and morphology of MIPs were characterized by infrared spectroscopy (IR) and scanning electron microscope (SEM). In order to evaluate the usability of the MIPs-coating, a methodology by combining MIPs-SBSE with high performance liquid chromatography (HPLC) detection for the determination of DES, dienestrol (DS), hexestrol (HS) and bisphenol (BPA) in complex samples was developed. Parameters that influenced the extraction efficiency such as extraction time, desorption solvent and desorption time were optimized. The results show that under the optimum extraction conditions, the MIPs-coated stir bar showed better extraction capacity and good selectivity than that of non-imprinted polymers (NIPs) coated stir bar to DES and its analogues. The MIPs-coated stir bars could be used at least 5 times without reduce of extraction ability. The linear ranges were 1.0 - 1000 μg/L for DES and BPA, 1.0 - 400 μg/Land 10.0 - 400 μg/L for DS and HS, respectively. The detection limits were within the range of 0.107 - 0.786 μg/L. The recoveries of the spiked milk samples were within the range of 73.60 - 96.30%, the RSDs were within 3.77 - 8.96%. The developed method is simple, selective, sensitive and applicable for the analysis of trace estrogen in complicated samples.
Template and target information: diethylstilbestrol, DES, dienestrol, DS, hexestrol, HS, bisphenol, BPA
Author keywords: atom transfer radical polymerization (ATRP), Diethylstilbestrol (DES), Estrogen, Magnetic Molecularly Imprinted Polymers (MMIPs), Stir bar sorptive extraction (SBSE)