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Abstract: The present work describes the preparation of a nanohybrid by a combination of the 2D graphene sheet and 0D graphene quantum dots (GQDs). The GQDs were prepared from-ánatural green precursors i.e. carrot juice by the one-step hydrothermal process. To get the maximum fluorescence property from nanohybrid, the graphene sheets were chemically doped with cadmium sulphide (CdS). The as prepared nanohybrid was characterized by means of X-ray diffraction analysis (XRD), field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), fluorescence and UV-vis spectroscopic techniques. The nanohybrid was further modified to design a nano-iniferter, which shows dual property i.e. works as polymerization initiator as well as provides platform for synthesis of the nimesulide-imprinted polymer. For designing of imprinted polymer two biocompatible monomers (cystine monomer and N-vinyl caprolactam) were used, which provides biodegradability to the polymer matrix. The imprinted polymer shows a very good selectivity towards the detection of nimesulide with a limit of detection as low as 6.65 ng L-1 (S/N=3). The sensor was also applied for the detection of nimesulide in real samples like human blood serum, plasma and urine samples as well as some pharmaceutical tablets
Template and target information: nimesulide
Author keywords: CdS-doped graphene oxide, Graphene quantum dots, Nano-iniferter, Nimesulide sensing, imprinted polymer