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Abstract: An innovative molecularly imprinted electrochemical sensor was fabricated based on reduced graphene oxide (RGO) and gold nanocomposite (Au) for rapid detection of vincristine (VCR). The RGO-Au composite membrane was obtained via direct one-step electrodeposition technique of graphene oxide (GO) and chloroauric acid (HAuCl4) on the surface of a glassy carbon electrode (GCE) by means of cyclic voltammetry (CV) in the potential range between -1.5 and 0.6 V in phosphate buffer solution (PBS) of pH 9.18, which is capable of effectively utilizing its superior electrical conductivity, larger specific surface area due to its synergistic effect between RGO and Au. The molecularly imprinted polymers (MIPs) were synthesized on the RGO-Au modified glassy carbon electrode surface with VCR as the template molecular, methyl acrylic acid (MAA) as the functional monomer, and ethylene glycol maleic rosinate acrylate (EGMRA) as a cross-linker. The performance of the sensor was investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) in detail. Under the optimum conditions, the fabricated sensor exhibited a linear relationship between oxidation peak current and VCR concentration over the range of 5.0 x 10-8 - 5.0 x 10-6 mol L-1 with a correlation coefficient of 0.9952 and a detection limit (S/N=3) of 2.6 x 10-8 mol L-1. The results indicated that the imprinted polymer films exhibited an excellent selectivity for VCR. The imprinted sensor was successfully used to determine VCR in real samples with recoveries of 90% -120% by using the standard addition method
Template and target information: vincristine, VCR
Author keywords: Molecularly imprinted polymers, Electrochemical sensor, reduced graphene oxide and gold nanocomposites, vincristine