MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Yano K, Nakagiri T, Takeuchi T, Matsui J, Ikebukuro K, Karube I
Article Title: Stereoselective recognition of dipeptide derivatives in molecularly imprinted polymers which incorporate an L-valine derivative as a novel functional monomer.
Publication date: 1997
Journal: Analytica Chimica Acta
Volume: 357
Issue: (1-2)
Page numbers: 91-98.
DOI: 10.1016/S0003-2670(97)00554-0

Abstract: A polymerizable L-valine derivative was synthesized for use as a novel functional monomer in molecular imprinting applications. This monomer is expected to form multiple hydrogen bonds with peptide derivatives, thus allowing a specific molecular memory in molecularly imprinted polymers. Several dipeptide derivatives were imprinted and the resulting polymers were used as stationary phases for liquid chromatography. It was shown that the molecularly imprinted polymers incorporating the L-valine derivative exhibited high diastereoselectivity to templates. A remarkable imprinting effect was observed when a Phe-Ala derivative was imprinted. High stereoselectivity of the imprinted polymer (separation factor alpha=2.84) suggested successful imprinting especially for a bulky template peptide. The ratios of template to functional monomer and solvent in the prepolymerization mixture were optimized. Moreover, it was demonstrated that the molecularly imprinted polymers possessed amino acid sequence selectivity as well as diastereoselectivity. (C) 1997 Elsevier Science B.V

  Krypton periodic table mug  Mug featuring the name PeptideChemist spelled out in the single letter amino acid code  I shop perodically customisable tote bag

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner