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Reference type: Journal
Authors: Yu YH, Ye L, de Biasi V, Mosbach K
Article Title: Removal of the fermentation by-product succinyl L-tyrosine from the b-lactamase inhibitor clavulanic acid using a molecularly imprinted polymer.
Publication date: 2002
Journal: Biotechnology and Bioengineering
Volume: 79
Issue: (1)
Page numbers: 23-28.
DOI: 10.1002/bit.10271

Abstract: Clavulanic acid is a beta-lactamase inhibitor used in therapeutic combinations with the penicillin-type antibiotics. During the fermentation leading to clavulanic acid, a succinyl L-tyrosine by-product is unavoidably formed. Occasionally, the amount of this by-product is found to be as high as 2% of the product even after standard purification operations. To further remove this impurity, we prepared a highly specific adsorbent for succinyl L-tyrosine with the molecular imprinting technique. This was performed by simultaneously using vinylbenzyl trimethylammonium chloride and methacrylic acid as the functional monomers. The imprinted polymer selectively bound succinyl L-tyrosine, and could be successfully used to remove this impurity at concentrations of less than 2% in the presence of clavulanic acid. (C) 2002 Wiley Periodicals, Inc

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