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Reference type: Journal
Authors: Zhu LL, Xu XJ
Article Title: Selective separation of active inhibitors of epidermal growth factor receptor from Caragana Jubata by molecularly imprinted solid-phase extraction.
Publication date: 2003
Journal: Journal of Chromatography A
Volume: 991
Issue: (2)
Page numbers: 151-158.
DOI: 10.1016/S0021-9673(03)00207-3
Alternative URL: http://www.chem.umb.edu/Chemistry/CH361/MIPEarlierWork.pdf

Abstract: A feasibility research was performed to study the possibilities of using a molecularly imprinted polymer as sorbent material in solid-phase extraction for the separation of active inhibitors of epidermal growth factor receptor (EGRF) from Caragana Jubata, a Chinese traditional Tibetan medicine. A molecularly imprinted polymer using quercetin. an active anti-EGFR inhibitor (IC50 = 15 muM), as the template and acrylamide as the functional monomer was prepared. The polymer was evaluated as a selective sorbent in molecularly imprinted solid-phase extraction. The EtOAc extract of Caragana Jubata was loaded on the polymer, and two novel active anti-EGFR inhibitors were found to be selectively retained after washing the polymer with appropriate solvent to disrupt the non-specific interactions occurring between the sample and the polymer matrix, which were identified as (E)-piceatannol (IC50 = 4.9 muM) and butein (IC50= 10 muM). The present work affords us a new potential method for selective separation of bioactive components from herb by using molecularly imprinted polymer as a solid-phase extraction adsorbent. (C) 2003 Elsevier Science B.V. All rights reserved

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