Authors: Hall AJ
, Achilli L
, Manesiotis P
, Quaglia M
, De Lorenzi E
, Sellergren B
A substructure approach toward polymeric receptors targeting dihydrofolate reductase inhibitors. 2. Molecularly imprinted polymers against Z-L-glutamic acid showing affinity for larger molecules.
Publication date: 2003
Journal: Journal of Organic Chemistry
Abstract: The preparation of a molecularly imprinted polymer against N-Z- L-glutamic acid using a novel bis-urea functional monomer is described. The polymer exhibits affinity for the template over N-Z-protected aspartic acid and glycine and, further, is capable of binding larger molecules, e.g., the anti-cancer drug methotrexate, containing the glutamate substructure
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