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Reference type: Journal
Authors: Svenson J, Karlsson JG, Nicholls IA
Article Title: H-1 nuclear magnetic resonance study of the molecular imprinting of (-)-nicotine: template self-association, a molecular basis for cooperative ligand binding.
Publication date: 2004
Journal: Journal of Chromatography A
Volume: 1024
Issue: (1-2)
Page numbers: 39-44.
DOI: 10.1016/j.chroma.2003.09.064

Abstract: In the present study, the interactions of components in a (-)- nicotine molecular imprinting polymerization mixture have been studied by H-1 NMR spectroscopy. The dissociation constants for complexation of template by a functional monomer analogue, acetic acid, have been determined. Nicotine was shown to self- associate at concentrations comparable to those used in previous molecular imprinting studies (app K-diss = 0.082 M in CDCl3 at 298 K). The extent of self-association was enhanced by the presence of acetic acid. Previous studies on (-)-nicotine- imprinted methacrylic acid-ethylene dimethacrylate co-polymers suggested the involvement of recognition sites for template- template complexes. Collectively these results provide the first direct evidence for the presence of template-template complexes, and support the previously hypothesized basis for cooperative ligand recognition events in this polymer system. (C) 2003 Elsevier B.V. All rights reserved

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