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Reference type: Journal
Authors: Li P, Hu JZ, Ling BP, Rong F, Yuan CW
Article Title: Preparation of molecularly imprinted polymer with racemic 2-chloromandelic acid and study on its chiral resolution.
Publication date: 2003
Journal: Acta Chimica Sinica
Volume: 61
Issue: (11)
Page numbers: 1885-1889.
Alternative URL: http://sioc-journal.cn/Jwk_hxxb/EN/abstract/abstract327523.shtml

Abstract: The molecularly imprinted polymer was prepared by racemic 2- chloromandelic acid as template and synthesized (S)-acryloyl-1- naphthylethylamine as chiral functional monomer. The molecularly imprinted polymers as stationary phase had good chiral resolution ability to 2-chloromandelic acid enantiomers and the separation factor a was calculated as 1.36. But this polymer showed no resolution to the analogues of the template, such as racemic 4-chloromandelic acid and mandelic acid. The structure of (S)-2-chloromandelic acid interacting with (S)- acryloy-1-naphthylethylamine was simulated by Hyperchem software. The S-S type of cavities left by imprinting in polymer matrix showed double recognition of spatial configuration and binding interaction and had stronger retention capability to ( S) -2-chloromandelic acid, so as to get the good enantioseperation
Template and target information: 2-chloromandelic acid

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