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Reference type: Journal
Authors: Wang DX, Hong SP, Row KH
Article Title: Chromatographic separation of xanthine derivatives on single and mixed-template imprinted polymers.
Publication date: 2004
Journal: Bulletin of the Korean Chemical Society
Volume: 25
Issue: (3)
Page numbers: 357-360.
Alternative URL: http://www.journal.kcsnet.or.kr/main/j_search/j_download.htm?code=B040307

Abstract: We developed in the present study molecular imprinted polymers (MIPs), using single templates (pentoxifylline, caffeine and theophylline) and mixed-templates (pentoxifyiline-caffeine, pentoxifylline-theophylline and caffeine-theophylline). The MIPs were prepared with methacrylic acid (MAA) as the monomer, ethylene glycol dimetharylate (EGDMA) as the crosslinker and 2,2'-azobis(isobutyronitrile) (AIBN) as the initiator. The obtained polymer particles (particle size after grinding was about 25-35 μm) were packed into a HPLC column (3.9 mm i.d. x 150 mm). The selectivity and chromatographic characteristics of the MIPs were studied using acetonitrile as the mobile phase at a flow rate of 0.8 mL/min. UV detector wavelength was set at 270 nm. Different single template MIPs showed different molecular recognitions to the templates and the structurally analogues, according to the rigidity and steric hindrance of the compounds. Recognition was improved on the mixed-template MIPs as a result of the cooperation or sum effect of the templates, whereas on the pentoxifylline-theophylline imprinted polymer, the highest selectivity and affinity were obtained. Separations of the test compounds on different polymers were also investigated
Template and target information: xanthines, xanthine mixtures, pentoxifylline, caffeine, theophylline, pentoxifyiline and caffeine, pentoxifylline and theophylline, caffeine and theophylline

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