MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Allender CJ, Brain KR, Heard CM
Article Title: Binding cross-reactivity of Boc-phenylalanine enantiomers on molecularly imprinted polymers.
Publication date: 1997
Journal: Chirality
Volume: 9
Issue: (3)
Page numbers: 233-237.
DOI: 10.1002/(SICI)1520-636X(1997)9:3<233::AID-CHIR5>3.0.CO;2-G

Abstract: A potential problem associated with molecularly imprinted polymer (MIP) sorbents is that of cross-reactivity. In this study three MIPs (imprinted with Boc-L-phenylalanine, Boc-L-alanine, Boc-L-glutamic acid) plus a non-imprinted control were prepared and examined for their ability to bind differentially the enantiomers of boc-protected phenylalanine in an effort to quantify cross-reactivity and to develop a predictive model. Batch rebinding studies showed a degree of predictability for a number of MIP-ligand pairs, but other combinations showed unexpectedly high levels of cross-reactivity. Despite the general acceptance of heterogeneity of MIP binding sites, many previous studies report linear Scatchard plots, which is indicative of binding site homogeneity. The data horn this study produced curves, dearly demonstrating heterogeneity, The theoretical and practical implications of this heterogeneity are discussed, Chirality 9:233-237, 1997. (C) 1997 Wiley-Liss, Inc

  I love MISPE shirt  Mug featuring the name Keith spelled out in the single letter amino acid code  British periodic table patriotic tote bag

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner