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Reference type: Journal
Authors: Huang JT, Zheng SH, Zhang JQ
Article Title: Molecularly imprinting of polymeric nucleophilic catalysts containing 4-alkylaminopyridine functions.
Publication date: 2004
Journal: Polymer
Volume: 45
Issue: (12)
Page numbers: 4349-4354.
DOI: 10.1016/j.polymer.2004.03.050

Abstract: Imidazole group of histidine residue is the essential catalytic group in the active site of a hydrolase protein. However, the imidazole is usually replaced with more nucleophilic 4-(N,N- dimethylamino)pyridines in organic syntheses. In order to introduce the supernucleophilic 4-dialkylaminopyridines into a catalytic site, a polymeric catalyst containing pyrrolidinopyridine moiety, is synthesized by imprinting of the bulk polymer with the transition state analogue of a substrate, accelerates the substrate-specific hydrolysis of p-nitrophenyl acetate. The results show that TSA-imprinted polymer containing 4-alkylaminopyridine groups is better than imidazole-appended polymer in artificial enzyme activity. (C) 2004 Elsevier Ltd. All rights reserved


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