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Reference type: Journal
Authors: Lin TY, Hu CH, Chou TC
Article Title: Determination of albumin concentration by MIP-QCM sensor.
Publication date: 2004
Journal: Biosensors and Bioelectronics
Volume: 20
Issue: (1)
Page numbers: 75-81.
DOI: 10.1016/j.bios.2004.01.028
Alternative URL: http://www.sciencedirect.com/science/article/B6TFC-4C0V67T-1/2/199e6ff9ef0dd3348215aae2f6301d09

Abstract: An MIP-QCM sensor able to detect micro-determine albumin concentrations was prepared by imprinting albumin with 3-dimethylaminopropyl methacrylamide-acrylate. The albumin MIP was coated on a QCM Au electrode. The adsorption characteristics of different electrodes, such as Au-OH, Au-COOH, Au-NH2 and Au electrodes, with albumin or mixture was examined. In the tetraethyleneglycol dimethacrylate crosslinking agent system, the adsorption capacity of different Au electrodes is in the order Au-OH > Au-COOH > Au-NH2 > Au. Additionally, the time taken to receive a steady-state frequency is in the order Au-NH2 Au-NH2 > Au-OH > Au-COOH electrode. Hence, the crosslinking agent had a significant effect on the MIP-QCM. On the adsorption selectivity, the albumin MIP-QCM exhibited higher response to albumin, the adsorption mass ratio of cytochrome c:lysozyme:albumin:myoglobin was 160:1:1942:30. On the other hand, in the non-MIP-QCM, the adsorption mass ratio of cytochrome c:lysozyme:albumin:myoglobin was 13:1:249:86. Additionally, a linear fitting was established and a clinical real sample was tested.This novel potential application of molecular imprinting to the recognition element of an MIP-QCM sensor appears to be promising


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