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Reference type: Journal
Authors: Martin PD, Jones GR, Stringer F, Wilson ID
Article Title: Comparison of extraction of a b-blocker from plasma onto a molecularly imprinted polymer with liquid-liquid extraction and solid phase extraction methods.
Publication date: 2004
Journal: Journal of Pharmaceutical and Biomedical Analysis
Volume: 35
Issue: (5)
Page numbers: 1231-1239.
DOI: 10.1016/j.jpba.2004.03.024

Abstract: An optimised solid phase extraction (SPE) method developed for the extraction of a structural analogue of the β-blocking drug propranolol from plasma utilising a molecularly imprinted polymer (MIP) has been compared with methods based on conventional liquid-liquid extraction (LLE), and SPE using C18-bonded and immobilised phenyl boronic acid (PBA). All four methods could be used for the extraction of the analyte with acceptable accuracy and precision. The MIP-based method, unlike the other methods required a protein precipitation step prior to extraction to eliminate the effects of co-extracted protein. The best performance was seen with the LLE method followed by SPE on the C18 phase. The MIP-based method represented no advantage over the comparator methods for this analyte. Indeed the performance of the MIP-based method was marginally worse as leaching of low level template impurities prevented detection of the target analyte at low concentrations (5 ng mL-1). This relatively poorer performance was evident as worse accuracy at low concentrations with a consequent higher limit of quantification than the conventional methods

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