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Reference type: Journal
Authors: Liu XY, Guan Y, Ding XB, Peng YX, Long XP, Wang XC, Chang K
Article Title: Design of temperature sensitive imprinted polymer hydrogels based on multiple-point hydrogen bonding.
Publication date: 2004
Journal: Macromolecular Bioscience
Volume: 4
Issue: (7)
Page numbers: 680-684.
DOI: 10.1002/mabi.200400031

Abstract: Weakly cross-linked temperature sensitive imprinted polymer hydrogels that recognize L-pyroglutamic acid (Pga) molecules via multiple-point hydrogen bonding were designed and synthesized. The amount of adsorption for Pga in imprinted hydrogels is 3-4 times higher than that in non-imprinted. The selectivity test of imprinted polymer gels was carried out by using a series of structurally related compounds Pga, pyrrolidine, 2-pyrrolidone, L-proline as substrates. The results show that imprinted polymer gels exhibit high sensitivity, special selectivity and reusability, suggesting that the polymer hydrogels would have an enormous potential for application in controlled drug release and seperation field

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