Authors: Caro E
, MarcÚ RM
, Cormack PAG
, Sherrington DC
, Borrull F
A new molecularly imprinted polymer for the selective extraction of naproxen from urine samples by solid-phase extraction.
Publication date: 2004
Journal: Journal of Chromatography B
Alternative URL: http://www.sciencedirect.com/science/article/B6X0P-4DPGW29-1/2/8b47c02a44be94044f60fd8f47df5546
Abstract: A non-covalent molecularly imprinted polymer (MIP) was synthesised using naproxen (a non-steroidal, anti-inflammatory drug (NSAID)) as a template molecule. The MIP was chromatographically evaluated to confirm the imprinting effect, and was then applied as a selective sorbent in solid-phase extraction (SPE) to selectively extract naproxen. After this study, the MIP was used to extract naproxen from urine samples; it was demonstrated that by applying a selective washing step with acetonitrile (ACN) the compounds in the sample that were structurally related to naproxen could be eliminated
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