Authors: Ciardelli G
, Cioni B
, Cristallini C
, Barbani N
, Silvestri D
, Giusti P
Acrylic polymeric nanospheres for the release and recognition of molecules of clinical interest.
Publication date: 2004
Journal: Biosensors and Bioelectronics
Alternative URL: http://www.sciencedirect.com/science/article/B6TFC-4CVV7P0-3/2/74e9f5307dbda01ba62ac2b796d80a3e
Abstract: Cross-linked poly(methylmethacrylate-co-methacrylic acid) nanospheres were imprinted with theophylline through template radical polymerisation in diluted acetonitrile solution. This study will focus on the effect of functional monomer nature used (methylmethacrylate and/or methacrylic acid) in the recognition and in the release of template in order to develop a material with combined properties of drug delivery and rebinding for clinical applications. After template extraction the nanospheres showed satisfactory recognition properties (up to 1 mg template/g of polymer). Moreover polymers prepared selectively removed theophylline with a theophylline rebinding of 5.1 times higher than that of caffeine, a compound of similar structure. Drug release properties were also satisfactory (up to 95% of loaded theophylline in 7 days)
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