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Reference type: Journal
Authors: O'Mahony J, Molinelli A, Nolan K, Smyth MR, Mizaikoff B
Article Title: Towards the rational development of molecularly imprinted polymers: 1H NMR studies on hydrophobicity and ion-pair interactions as driving forces for selectivity.
Publication date: 2005
Journal: Biosensors and Bioelectronics
Volume: 20
Issue: (9)
Page numbers: 1884-1893.
DOI: 10.1016/j.bios.2004.07.036
Alternative URL: http://www.florafaunagardens.com/BlackTusk/Wine%20Research/Towards%20the%20rational%20development%20of%20molecularly%20imprinted%20polymers%20-%201H%20NMR%20studies%20on%20hydrophobicity%20and%20ion-pair%20interactions%20as%20driving%20forces%20for%20selectivity.pdf

Abstract: The preparation of molecularly imprinted polymers (MIP) based on non-covalent interactions has become a widely used technique for creating highly specific sorbent materials predominantly used in separation chemistry. A crucial factor in a successful imprinting protocol is the optimisation of the template/functional monomer interaction in the pre-polymerisation mixture, eventually leading to a maximum of high-affinity binding sites in the resulting polymer matrix. In order to develop more efficient preparation technologies for imprinted polymers, two separate pre-polymerisation complexes were investigated by NMR spectroscopic techniques in order to identify the types of interactions occurring in the pre-polymerisation mixture, and their implications for the subsequently formed imprinted polymer. In particular, hydrophobic effects have been followed by NMR spectroscopy and their contribution to the selectivity of the resulting MIP has been investigated. The 2,4-D imprint system is used as an example to fundamentally study whether observations at the pre-polymerisation stage correlate with properties of the finally prepared MIP, and which parameters govern success of an imprinting protocol
Template and target information: 2,4-dichlorophenoxyacetic acid, 2,4-D, Norephedrine, NEP
Author keywords: molecularly imprinted polymer (MIP), non-covalent imprinting, NMR, complexation, 2,4-dichlorophenoxyacetic acid (2,4-D), Norephedrine (NEP)

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