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Reference type: Journal
Authors: Burkett CM, Edmiston PL, Lloyd JA
Article Title: Selective binding of nitroaromatic compounds by molecularly imprinted sol-gel materials: Progress towards a chemical sensor for TNT.
Publication date: 2004
Journal: Abstracts of Papers of the American Chemical Society
Volume: 227
Issue: (ANYL)
Page numbers: 121.
Alternative URL: http://www.chemistry.org/portal/resources/ACS/Subportals/analytical/anyl_sep_0304.pdf

Abstract: Sol-gel materials for use in chemical sensors were molecularly imprinted for nitroaromatic compounds using a sacrificial spacer template. The template was covalently bonded to the sol-gel matrix during formation, which was then removed to yield a binding pocket with the proper shape and chemical functionality to bind trinitrotoluene (TNT). The sol-gel composition and processing conditions were varied to optimize selectivity for TNT. An equilibrium binding assay involving HPLC was used to measure the affinity of the imprinted sol-gels for TNT versus structural analogues. Infrared spectroscopy and nitrogen adsorption measurements were used in combination with the binding data to evaluate how template type, sol-gel composition, and porosity can be optimized for chemical sensor applications. The use of the imprinted sol-gels to create an optical sensor for TNT will be discussed.

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