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Abstract: A molecular imprinting-chemiluminescence method for the determination of phenacetin was established by using phenacetin-imprinted polymer as recognition material and KMnO4- phenacetin-formaldehyde reaction as detection system. It was found that a weak chemiluminescence (CL) was produced from the reaction of KMnO4 with phenacetin. The CL signal was greatly increased by formaldehyde. Phenacetin-imprinted polymer was synthesized using methacrylic acid as functional monomer and ethylene glycol dimethacrylate as cross-linker. The chemiluminescence intensity responded linearly to the concentration of phenacetin within 5.0 x 10(-7) similar to5.0 x 10(-5) g/mL with a detection limit of 2 x 10(-7) g/mL. The relative standard deviation for 1.0 x 10(-6) g/mL of phenacetin was 2.8% (n = 11). The method has been applied to the determination of phenacetin in amidopyrini et paracetamdi compositae and in urine samples. The results were in good agreement with those obtained by pharmacopoeia method and the recovery results were satisfactory
Template and target information: phenacetin
Author keywords: chemiluminescence, molecularly imprinting, phenacetin, potassium permanganate