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Reference type: Journal
Authors: Ersöz A, Denizli A, Özcan A, Say RI
Article Title: Molecularly imprinted ligand-exchange recognition assay of glucose by quartz crystal microbalance.
Publication date: 2005
Journal: Biosensors and Bioelectronics
Volume: 20
Issue: (11)
Page numbers: 2197-2202.
DOI: 10.1016/j.bios.2004.07.030
Alternative URL: http://www.sciencedirect.com/science/article/B6TFC-4D98XK1-3/2/0109b28e6944f4bed1b7337b54b1066a

Abstract: Molecular imprinted polymers (MIP) as a recognition element for sensors are increasingly of interest and MIP-quartz crystal microbalance (QCM) have started to appear in the literature. In this study, we have combined quartz crystal microbalance with MIP to prepare a sensor using the ability of glucose to chelate of copper (II) ion of methacrylamidohistidine (MAH) monomer to create ligand exchange (LE) assembled monolayer which is suitable for glucose determination. The study includes the measurement of binding interaction of molecularly imprinted QCM sensor via ligand interaction, investigation of the pH effect on frequency shift and recognition selectivity studies of glucose-imprinted polymer with respect to methyl-α-d-glucopyranoside and sucrose. Bmax (number of binding sites) and KD (dissociation constant of the metal-chelate copolymer) were also calculated using Scathard plot and the detection limit was found as 0.07 mM. MIP showed higher glucose-binding affinity than a well-known glucose binding protein, conconavalin A
Template and target information: glucose
Author keywords: molecular imprinting, MIP, QCM, glucose sensor, ligand exchange

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