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Reference type: Journal
Authors: Rathbone DL, Ali A, Antonaki P, Cheek S
Article Title: Towards a polymeric binding mimic for cytochrome CYP2D6.
Publication date: 2005
Journal: Biosensors and Bioelectronics
Volume: 20
Issue: (11)
Page numbers: 2353-2363.
DOI: 10.1016/j.bios.2005.01.009
Alternative URL: http://www.sciencedirect.com/science/article/B6TFC-4FCG23Y-2/2/03d1fabd984e3b7389d0af0d199269c8

Abstract: A series of fluorescent molecularly imprinted polymers has been prepared with a view to generating material capable of mimicking the binding characteristics of the metabolically important cytochrome isoform CYP2D6. Such polymers would have the possibility to form the sensing element in a high-throughput assay for the prediction of CYP2D6 affinity. The imprinted polymers possessed binding-dependent fluorescence. They re-bound their templates and various cross-reactivities were encountered for test compound/drug recognition. One polymer in particular exhibited a rational discrimination amongst the related synthetic templates and was reasonably successful in recognising CYP2D6 substrates from a drug panel
Template and target information: CYP2D6
Author keywords: molecularly imprinted polymer, fluorescence, CYP2D6, Binding mimic


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