MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Journal
Authors: Rathbone DL, Ali A, Antonaki P, Cheek S
Article Title: Towards a polymeric binding mimic for cytochrome CYP2D6.
Publication date: 2005
Journal: Biosensors and Bioelectronics
Volume: 20
Issue: (11)
Page numbers: 2353-2363.
DOI: 10.1016/j.bios.2005.01.009
Alternative URL: http://www.sciencedirect.com/science/article/B6TFC-4FCG23Y-2/2/03d1fabd984e3b7389d0af0d199269c8

Abstract: A series of fluorescent molecularly imprinted polymers has been prepared with a view to generating material capable of mimicking the binding characteristics of the metabolically important cytochrome isoform CYP2D6. Such polymers would have the possibility to form the sensing element in a high-throughput assay for the prediction of CYP2D6 affinity. The imprinted polymers possessed binding-dependent fluorescence. They re-bound their templates and various cross-reactivities were encountered for test compound/drug recognition. One polymer in particular exhibited a rational discrimination amongst the related synthetic templates and was reasonably successful in recognising CYP2D6 substrates from a drug panel
Template and target information: CYP2D6
Author keywords: molecularly imprinted polymer, fluorescence, CYP2D6, Binding mimic

  mipdatabase.com logo special offer joke shirt  Lab Honey Periodic table mug  HE-MAN polymer chemistry shirt

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner