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Reference type: Journal
Authors: Zurutuza A, Bayoudh S, Cormack PAG, Dambies L, Deere J, Bischoff R, Sherrington DC
Article Title: Molecularly imprinted solid-phase extraction of cocaine metabolites from aqueous samples.
Publication date: 2005
Journal: Analytica Chimica Acta
Volume: 542
Issue: (1)
Page numbers: 14-19.
DOI: 10.1016/j.aca.2004.12.019
Alternative URL: http://www.sciencedirect.com/science/article/B6TF4-4F8TK92-2/2/b6de079e1fc06c89c30d3e02e78fb798

Abstract: Cocaine is a well-known drug of abuse which, when ingested nasally or by smoking, undergoes a number of biotransformation and degradation reactions. In the present work, a synthetic analogue of the cocaine metabolite benzoylecgonine was prepared and used as a template molecule in the preparation of a series of molecularly imprinted polymers (MIPs). Molecularly imprinted solid-phase extraction (MISPE) conditions were established under which benzoylecgonine in aqueous samples could be selectively extracted and quantified at clinically relevant concentrations (μg/ml). Under optimised MISPE conditions, recoveries of analyte were high (>70%) and excellent discrimination between imprinted and non-imprinted materials observed
Template and target information: benzoylecgonine, cocaine metabolites
Author keywords: Molecularly imprinted polymers, Solid-phase extraction, Cocaine, Cocaine metabolites, Benzoylecgonine

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