Abstract: A robust, Cu-complexing polymer (TACN-Cu2+ contg.) is described that can be used to monitor glucose concn. in complex biol. samples, e.g., blood plasma. The approach to monitor glucose concn. uses ligand exchange on the TACN-Cu2+ complex which is incorporated into a hydrophilic, porous polymer matrix to provide a platform for a sensor. A polymerizable styryl-TACN-Cu2+ complex was synthesized as the functional monomer that was crosslinked by N,N'-methylenebisacrylamide to produce a microporous polymer that still binds glucose but excludes larger mols. such as glycoproteins that might otherwise bind to the metal complex. This approach, which combines metal coordination/chelation for sugar binding, ligand exchange for signal transduction, and mol. imprinting to create a polymer platform and potentially enhance binding selectivity, is promising for developing simple, stable, and inexpensive sensors for monitoring glucose concns. in clin. diagnostic and bioprocess applications.
Template and target information: glucose