MIPs logo MIPdatabase    HoHoHo Use this space
Custom Search
Reference type: Journal
Authors: Lindsey JS
Article Title: Self-assembly in synthetic routes to molecular devices - biological principles and chemical perspectives - a review.
Publication date: 1991
Journal: New Journal of Chemistry
Volume: 15
Issue: (2-3)
Page numbers: 153-180.

Abstract: Molecular electronics places a premium on organized 3- dimensional architectures. Self-assembly has been touted as a solution to the synthesis problems of molecular electronics. Biological self-assembly provides striking illustrations of thermodynamically-stable architectures, including tobacco mosaic virus, DNA, and numerous multimeric proteins. But in many other instances biological self-assembly is regulated in a number of characteristic ways. Seven classifications of self- assembly processes are introduced, including strict (equilibrium) self-assembly, irreversible self-assembly, assembly following precursor modification, assembly with post- modification, assisted assembly, directed assembly, and assembly with intermittent processing. Strict self-assembly is governed by equilibrium thermodynamics. The virtues of self- assembly include minimization of information through use of modular subunits, control of assembly and disassembly, built-in error-checking and recovery, and overall high efficiency. In many but not all instances self-assembly is a cooperative process involving nucleation and growth phases. A fundamental theme of cooperative assembly processes is that one series of interactions establishes the initial structure (nucleation), thereby setting the stage for a subsequent and more extensive series of interactions (growth). Cooperative phenomena are well-known in biochemistry, but cooperative assembly is not as well-developed conceptually in synthetic chemistry. A striking feature of self-assembly is that forming several bonds can be easier than forming only one bond. Self-assembly can involve non-covalent and covalent bond formation. Self-assembly lies at the heart of myriad examples in chemistry, ranging from metal chelation to model systems for self-replication. Multi- bridged cage molecules provide one domain for comparing modern methods of one-flask syntheses with biological self-assembly, and the syntheses of over 100 such cage molecules are reviewed. The rich precedents of biological self-assembly may yield new paradigms for synthetic chemistry. Molecular electronics is not alone in its requirement for controlled 3-dimensional architectures, and a deeper understanding of self-assembly in all its manifestations is expected to benefit many fields of chemistry

  I love MISPE mug  multi MIPs logo mug  British periodic table patriotic tote bag

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner