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Reference type: Journal
Authors: Lee SH, Doong RA
Article Title: Molecularly imprinted polymers for the effective recognition of estrodiols.
Publication date: 2005
Journal: Abstracts of Papers of the American Chemical Society
Volume: 229
Issue: (ANYL)
Page numbers: 045.
Alternative URL: http://www.chemistry.org/portal/resources/ACS/Subportals/analytical/anyl_spring05.pdf

Abstract: Molecularly imprinted polymers (MIPs) are smart polymers that can be served as biomimic enzymes for biosensor applications. Estrodiol is an endocrine disruptor which has been suspected to cause disruption in the endocrine system. In this study, a new procedure for fabricating the estradiol-based molecularly imprinted polymer was developed. The effect of monomers on specificity was also examined. Estradiol-imprinted polymer was prepared in bulk polymerization by non-covalent binding. Estradiol and methacrylic acid were used as template and functional monomer, respectively . After adding ethylene glycol dimethacrylate and azobisisobutyronitrile, solutions were heated to 60 deg-C to form polymers. UV/vis spectroscopic results showed that estradiol can be completely removed by acetonitrile. Carbonyl and hydroxyl groups were clearly appeared in FT-IR spectra. In addition, the specific surface area of MIPs increased from 129 to 172 m2 /g after the removal of template, depicting the high capability of the developed MIP s. Moreover, columns packed with MIPs can effectively separate 17β-estradiol from other steroids as well as polycylic aromatic hydrocarbons (PAHs) with similar structures and/or shapes, showing the feasibility of using the developed MIPs for biosensor applications.
Template and target information: 17β-estradiol

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