Authors: Tremblay M
, Voyer N
Enhanced activity of a-chymotrypsin in organic media using designed molecular staples.
Publication date: 2005
Abstract: We report the enhancement of a-chymotrypsin activity in organic solvents using modified peptides bearing two crown ethers. The transesterification of N-acetyl-L-phenylalanine ethyl ester with 1-propanol was used as model reaction. Co-lyophilization of crown ether modified peptides with a-chymotrypsin prior to use resulted in an increase of enzyme catalytic activity in non-aqueous media. The efficiency of enzyme activation is dependent on the amino acid sequence of peptidic additives and on the positions of the amino acids bearing the crown ligand
Template and target information: bioimprinting
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