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Proceedings title: Polymer Preprints, Japan
Volume number: 51m

Abstract: We prepared the molecularly imprinted polymers (MIPs) for cinchonidine by the use of vinyl-substituted metalloporphyrin and methacrylic acid as functional monomers. The MIPs prepared by both functional monomers demonstrated the higher binding ability for cinchonidine in chromatographic tests using the MIPs-packed columns compared with the MIPs prepared by the use of methacrylic acid or metalloporphyrin, independently, as a functional monomer. The MIPs containing a zinc(II)-porphyrin in the binding site showed fluorescence quenching by the binding of cinchonidine. The nonlinear correlation between the quenching and the concentration of cinchonidine incubated indicates that the fluorescence quenching is based on the specific binding of cinchonidine to MIP. These results reveal that metalloporphyrin-based MIPs can be applied to the tailor-made sensing materials responding to the binding event of a template molecule.