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Reference type: Conference Proceeding
Authors: Takeuchi A, Fujimoto K
Publication date: 2002
Article title: Modification of cell surfaces with polymer chains for introducing chemically reactive sites and application to tissue regeneration.
Page numbers: 768
Alternative URL: http://www.jstage.jst.go.jp/article/spsjppj/51m/0/51m_768/_article

Proceedings title: Polymer Preprints, Japan
Volume number: 51m

Abstract: We developed a method to create recognition system on cell surfaces. Bifunctional polymer chains were introduced to cell membrane through a bio-affinity. Polymer chains. (RGDS-PEO-PDP) were synthesized by coupling a cell-binding peptide, Arg-Gly-Asp-Ser (RGDS), and N-Succinimidyl 3-(2-pyridyldithio)propionate (SPDP) to poly(ethylene oxide) (PEO) chains, which possessed RGDS at one end and pyridyldithiol moiety at another end. U937 cells and human umbilical vein endothelial cells (HUVEC) were modified with RGDS-PEO-PDP. Both modified cells selectively attached to SH-bearing surfaces compared with OH-bearing surfaces. When modified cells were allowed to bind to a surface as a template for "imprinting", we could observe that unmodified U937 cells assembled along the template. Therefore, these modified cells might be regarded as "Commander cells" to instruct unmodified cells to begin the ordering. Our developed technique will be useful for cell aggregation and delivery, and tissue regeneration.


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