MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Yin JF, Yang GL, Chen Y
Article Title: Rapid and efficient chiral separation of nateglinide and its l-enantiomer on monolithic molecularly imprinted polymers.
Publication date: 2005
Journal: Journal of Chromatography A
Volume: 1090
Issue: (1-2)
Page numbers: 68-75.
DOI: 10.1016/j.chroma.2005.08.020
Alternative URL: http://www.sciencedirect.com/science/article/B6TG8-4GNKRP7-6/2/8a001a33fdad276494de9fc5557865cb

Abstract: A monolithic molecularly imprinted polymer (monolithic MIP) was designed and prepared for chiral separation of nateglinide and its l-enantiomer. The enantiomers were rapidly separated on this novel monolithic MIP based chiral stationary phase (MIP-CSP), whereas the enantioseparation was not obtained on the non-imprinted polymer (NIP). Chiral recognition was found to be dependent on the stereo structures and the arrangement of functional groups of the imprinted molecule and the cavities on MIP. Thermodynamic data (Δ Δ H and Δ Δ S) obtained by Van't Hoff plots revealed an enthalpy-controlled enantioseparation. The binding capacity was evaluated by frontal analysis. Monolithic nateglinide-MIP had an effective number of binding sites Bt = 41.15 μmol g-1 with a dissociation constant of Kd = 7.40 mM. The morphological characteristics of the monolithic MIP were investigated by pore analysis and scanning electron microscope (SEM). Results showed that both mesopores and macropores were formed in the monolith. Over all, this study presents a new and practical possibility for providing high rates of mass transfer, fast separations and high efficiencies without the pressure constraints of the traditional bulk molecularly imprinted polymers, through the monolithic MIPs
Template and target information: nateglinide
Author keywords: molecularly imprinted polymer, monolithic column, chiral separation, chiral stationary phases, nateglinide

  Eat, sleep, imprint, repeat greetings card  SMI logo mug  Man of proper-tea mug in green

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner