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Reference type: Journal
Authors: Kotrotsiou O, Kotti K, Dini E, Kammona O, Kiparissides C
Article Title: Nanostructured materials for selective recognition and targeted drug delivery.
Publication date: 2005
Journal: Journal of Physics: Conference Series
Volume: 10
Page numbers: 281-284.
DOI: 10.1088/1742-6596/10/1/069
Alternative URL: http://iopscience.iop.org/1742-6596/10/1/069

Abstract: Selective recognition requires the introduction of a molecular memory into a polymer matrix in order to make it capable of rebinding an analyte with a very high specificity. In addition, targeted drug delivery requires drug-loaded vesicles which preferentially localize to the sites of injury and avoid uptake into uninvolved tissues. The rapid evolution of nanotechnology is aiming to fulfill the goal of selective recognition and optimal drug delivery through the development of molecularly imprinted polymeric (MIP) nanoparticles, tailor-made for a diverse range of analytes (e.g., pharmaceuticals, pesticides, amino acids, etc.) and of nanostructured targeted drug carriers (e.g., liposomes and micelles) with increased circulation lifetimes. In the present study, PLGA microparticles containing multilamellar vesicles (MLVs), and MIP nanoparticles were synthesized to be employed as drug carriers and synthetic receptors respectively.
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