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Reference type: Journal
Authors: Li P, Rong F, Xie YB, Zhu ZL, Yuan CW
Article Title: Study on binding characteristics of (S)-naproxen imprinted polymer and performance of its complexes during preparation.
Publication date: 2003
Journal: Journal of Southeast University (Natural Science Edition)
Volume: 33
Issue: (4)
Page numbers: 475-478.
Alternative URL: http://en.cnki.com.cn/Article_en/CJFDTotal-DNDX200304022.htm

Abstract: A molecularly imprinted polymer (MIP) was synthesized as the highly chiral selective materials for (S)-naproxen with acrylamide as functional monomers. UV (ultra-violet) studies showed that the template (S)-naproxen and functional monomer acrylamide formed complexes before polymerization and Hyperchem was used to simulate the structures of complexes. The binding capacity of MIP to (S)-naproxen is higher than that of its enantiomer and the chiral separation factor ? is 1.87. Scatchard analysis suggests the MIP recognizing (S)-naproxen with two classes of binding sites. The calculated dissociation constant Kd,1 and apparent maximum number Qmax,1 of binding sites with high affinity are 28.0 ?mol/L and 52.94 ?mol/g respectively, while Kd,2 and Qmax,2 of binding sites with low affinity are 0.489 mmol/L and 0.122 mmol/g
Template and target information: (S)-naproxen

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