MIPdatabase
Authors: Sui HY, Li HQ, Shen ZY
Article Title: Chiral separation of amino acid derivatives by molecular imprinting technique (I) - Preparation of molecularly imprinted polymers, chromatographical evaluation and physical and chemical character formulation.
Publication date: 2003
Journal: Fine Chemicals
Volume: 20
Issue: (6)
Page numbers: 345-348+373.
Alternative URL: http://en.cnki.com.cn/Article_en/CJFDTotal-JXHG200306009.htm
Abstract: Syntheses of molecularly imprinted polymers against L-t-butoxycarbonyl-tryptophan or D-t-butoxycarbonyl-tryptophan using molecular imprinting technique were reported.This kind of polymers was systematically evaluated by liquid chromatography and frontal chromatography.The results suggested that the dissociation constant for the L-enantiomer,the imprinting molecule,was lower than that for the D-enantiomer(3.287 mmol/L and 4.379 mmol/L, respectively), which means that the affinity for the L-enantiomer is higher than that for the D-enantiomer,therefore the polymer has special affinity with the template.The physical and chemical character formulations of the molecularly imprinted polymer further indicated that it is a polymer with multihole structure which provides good diffusion channels for the solutes,and there are some functional groups in the molecularly imprinted polymer which can interact with the template.
Template and target information: L-t-butoxycarbonyl-tryptophan, D-t-butoxycarbonyl-tryptophan
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