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Reference type: Journal
Authors: Ansell RJ
Article Title: Molecularly imprinted polymers for the enantioseparation of chiral drugs.
Publication date: 2005
Journal: Advanced Drug Delivery Reviews
Volume: 57
Issue: (12)
Page numbers: 1809-1835.
DOI: 10.1016/j.addr.2005.07.014
Alternative URL: http://www.sciencedirect.com/science/article/B6T3R-4HGD70K-1/2/317a1927b5bf86d6d2e7b3afbb781841

Abstract: Molecularly imprinted polymers have been applied for many years in chiral separations and increasingly have been applied to drugs. Separation speed and efficiency in methods such as HPLC and CEC are increasingly competitive with alternative established CSPs. The literature on separation of drug enantiomers using MIPs via HPLC, TLC, SFC and CEC are reviewed. Issues for method development, particularly the monomer-template interactions during the imprinting process, and the mechanism of solute retention on MIP CSPs in chromatography using normal phase or reverse-phase mobile phases are considered
Template and target information: Review - MIPs in enantioseparation of drugs
Author keywords: enantiomers, Chiral stationary phase (CSP), high performance liquid chromatography (HPLC), Thin layer chromatography (TLC), Supercritical fluid chromatography (SFC), capillary electrochromatography (CEC)


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