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Reference type: Journal
Authors: Rathbone DL
Article Title: Molecularly imprinted polymers in the drug discovery process.
Publication date: 2005
Journal: Advanced Drug Delivery Reviews
Volume: 57
Issue: (12)
Page numbers: 1854-1874.
DOI: 10.1016/j.addr.2005.07.017
Alternative URL: http://www.sciencedirect.com/science/article/B6T3R-4HB4D8D-1/2/e57ddf44b3ee9e4015464a1c5a0bd4f4

Abstract: Since molecularly imprinted polymers (MIPs) are designed to have a memory for their molecular templates it is easy to draw parallels with the affinity between biological receptors and their substrates. Could MIPs take the place of natural receptors in the selection of potential drug molecules from synthetic compound libraries? To answer that question this review discusses the results of MIP studies which attempt to emulate natural receptors. In addition the possible use of MIPs to guide a compound library synthesis towards a desired biological activity is highlighted
Template and target information: Review - MIPs in drug discovery
Author keywords: combinatorial chemistry, molecular imprinting, receptor mimics, cross-reactivity, Multiple templates, Composite template


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