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Abstract: A series of Morin-imprinted polymers were prepared and their adsorption properties for the template were evaluated by binding experiments.The results show that the polymer prepared by using acrylamide as the functional monomer,CH-3CO-2Et as the porogen exhibited a higher selectivity for Morin and good affinity to its structural analogues.The molar ratio of template to functional monomer in the pre-polymeric mixture was optimized.Scatchard analysis shows that a equal class of binding sites were formed in the imprinted polymer in the studied concentration range.The dissociation constant and the apparent maximum number of the binding sites were 0.877 mmol/L and 59.18 μmol/g,respectively.The function of the functional groups of the template in the formation of complementary interacting site in the polymer was discussed.It was concluded that the hydrogen bonds formed between the C-3—OH,C-7—OH,C-4'—OH of Morin and acrylamide played an important role in molecular recognition.Using the Morin-imprinted polymers as thin layer chromatographic stationary phase can separate the template from the other compounds.The minimal value of R-s to its structural analogue compound was 1.19.
Template and target information: morin
Author keywords: molecular imprinting, morin, acrylamide, substrate selectivity, thin layer chromatography