Abstract: Microsystem technology offers us numerous active devices by fabricating small features on a variety of substrates to satisfy a set of our demands in miniaturization. Since we have been seeking precision microdevices with enhanced performance at small scale, here we introduced a 'microfluidic approach' for the synthesis of new materials, which hitherto have not been possible from conventional synthetic approach. The use of microreactors for synthetic chemistry offers a number of potential advantages over existing chemical technology. Chemical reactions run in microfluidic devices have high thermal and mass transfer rates with an opportunity to use more aggressive reaction conditions allowing for improved product yield. The overall goal is to carry out all operations normally performed in a chemical laboratory including synthesis, processing, purification and analysis on one microfluidic device efficiently and economically using minute amounts of solvents and reagents. For example, we demonstrated here a microfluidic synthesis of functional molecularly imprinted polymer (MIPs) particles by using a novel microfluidic reactor to produce 'monoclonal MIPs particles', which have only high affinity binding sites to achieve high performance molecular recognition function in chemical or bio-detective technology. We also synthesized nano-sized semiconductor particles by continuous, dynamic fusion method using a specially designed microfluidic reactor.