MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Lakshmi D, Sharma PS, Prasad BB
Article Title: Development of uric acid sensor based on molecularly imprinted polymer-modified hanging mercury drop electrode.
Publication date: 2006
Journal: Electroanalysis
Volume: 18
Issue: (9)
Page numbers: 918-927.
DOI: 10.1002/elan.200603478

Abstract: Uric acid (UA) sensor based on molecularly imprinted polymer-modified hanging mercury drop electrode was developed for sensitive and selective analysis in aqueous and blood serum samples. The uric acid-imprinted polymer was prepared from melamine and chloranil and coated directly onto the surface of a hanging mercury drop electrode, under charge-transfer interactions at +0.4V (vs. Ag/AgCl), in model 303A electrode system connected with a polarographic analyzer/stripping voltammeter (PAR model 264A). The binding event of uric acid was detected in the imprinted polymer layer through differential pulse, cathodic stripping voltammetry (DPCSV) at optimized operational conditions [accumulation potential +0.4V (vs. Ag/AgCl), accumulation time 120s, pH7.0, scan rate 10mV s-1, pulse amplitude 25mV]. The limit of detection for UA was found to be 0.024 μg mL-1 (RSD=0.64%, S/N=3). Under the optimized operational conditions, the sensor was able to differentiate between uric acid and other closely structural-related compounds and interfering substances. Ascorbic acid (AA), a major interferent in UA estimation, was not adsorbed on the surface of sensor electrode. The present sensor is, therefore, UA-selective at all concentrations of AA present in human blood serum samples. The précised and accurate quantification of UA have been made in the dilute as well as concentrated regions varying within limits 0.1-4.0 and 9.8-137.0 μg mL-1, respectively
Template and target information: uric acid
Author keywords: Uric acid sensor, Molecularly imprinted polymer-modified hanging mercury drop electrode, differential pulse, Cathodic stripping voltammetry, Human blood serum

  Hat featuring the name Sonali spelled out in symbols of the chemical elements  Chemistry peptide mug  Beach bunny periodic table shirt

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner