MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Xu ZF, Liu L, Deng QY
Article Title: Study on the mechanism of binding specificity of metoclopramide-imprinted polymers.
Publication date: 2006
Journal: Journal of Pharmaceutical and Biomedical Analysis
Volume: 41
Issue: (3)
Page numbers: 701-706.
DOI: 10.1016/j.jpba.2006.01.043
Alternative URL: http://www.sciencedirect.com/science/article/B6TGX-4JBGJ2R-6/2/68da6249345dfe61ddf1792f95805a6e

Abstract: A series of metoclopramide (MCP)-imprinted polymers utilizing methacrylic acid or 2-vinylprindine (2-VP) as functional monomer and chloroform, acetonitrile or methanol as porogen were prepared. The affinity and specificity of these polymers were evaluated by equilibrium binding experiments. Proton NMR model studies on interactions between the template and functional monomer analogues, acetic acid and d5-pyridine, were performed in the same solvents that were used as porogens for the molecularly imprinted polymers (MIPs). A correlation was found to exist between the binding strength and specificity of a particular polymer and the extent of monomer-template interactions shown by the corresponding NMR spectrum. So, a useful means is provided to predict the performance of a MIP in this paper. Based on the results of NMR experiments and selectivity experiments, the role of functional groups of the template in the formation of complementary interacting sites in the polymer in different porogens was discussed, and the mechanism of molecular recognition of the MIPs was proposed
Template and target information: metoclopramide, MCP
Author keywords: molecular imprinting, Metoclopramide, hydrogen bonding, NMR, molecular recognition


  Periodic table Soup - the chemical formula for soup apron  Periodic table Bag bag  Meerkat somebody mention coffee mug

Molecules Special Issue call      Appeal for information






 

Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:



Mickey Mouse 90th Anniversary banner