MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Lin LQ, Li YC, Fu Q, He LC, Zhang J, Zhang QQ
Article Title: Preparation of molecularly imprinted polymer for sinomenine and study on its molecular recognition mechanism.
Publication date: 2006
Journal: Polymer
Volume: 47
Issue: (11)
Page numbers: 3792-3798.
DOI: 10.1016/j.polymer.2006.03.083
Alternative URL: http://www.sciencedirect.com/science/article/B6TXW-4JVTCJ7-3/2/459e33339740ecc1b8441c6996661a85

Abstract: A sinomenine (SIN) molecule-imprinted monolithic stationary phase (MIMSP) with specific recognition for SIN was prepared by in situ technique, utilizing methacrylic acid (MAA) as a function monomer, ethylene glycol dimethacrylate (EDMA) as a cross-linking agent, and low-polar solvents (toluene and dodecanol) as porogenic solvents. The selectivity of the polymers for SIN was evaluated by high performance liquid chromatography (HPLC). Some chromatographic conditions, such as the column temperature, the flow rate and the composition of the mobile phase, were changed in order to characterize the chromatographic procedure. SIN could be separated from some other structural analogues, including morphine, codeine, codethyline and magnoflorine, under optimized conditions. Scatchard analysis showed that two classes of binding sites existed in the SIN-imprinted polymers, with their dissociation constants estimated to be 7.257 x 10-5 and 3.828 x 10-3 mol l-1, respectively. Compared with the SIN-imprinted polymers, the non-imprinted polymers prepared using the same method but in the absence of SIN did not exhibit the specific molecular selectivity, which suggests that the specific molecule-recognition ability of the SIN-imprinted polymers was largely ascribed to the imprinting effect
Template and target information: sinomenine, SIN
Author keywords: molecularly imprinted polymer, Sinomenine, In situ technique

  I love MIPs bag  multi MIPs logo mug  British periodic table patriotic tote bag

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner