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Reference type: Journal
Authors: Ye L, Yoshimatsu K, Kolodziej D, Da Cruz Francisco J, Dey ES
Article Title: Preparation of molecularly imprinted polymers in supercritical carbon dioxide.
Publication date: 2006
Journal: Journal of Applied Polymer Science
Volume: 102
Issue: (3)
Page numbers: 2863-2867.
DOI: 10.1002/app.24648
Alternative URL: http://teresacasimiro.com.sapo.pt/Bibliographic_References/23.pdf

Abstract: Molecularly imprinted polymer nanoparticles were prepared in supercritical carbon dioxide using a noncovalent imprinting approach. In the present work, propranolol was used as a model template, methacrylic acid as a functional monomer, and divinylbenzene as a crosslinker. Under a high dilution condition, the heterogeneous polymerization resulted in discrete crosslinked polymer nanoparticles. Compared with the nonimprinted polymers, the imprinted nanoparticles displayed much higher propranolol uptake in a low polarity organic solvent. The use of a single enantiomer (S)-propranolol as the template clearly demonstrated that the imprinted binding sites are chiral-selective, with a cross-reactivity towards (R)-propranolol of less than 5%. The overall binding performance of the imprinted nanoparticles was comparable to imprinted polymers prepared in conventional organic solvents. 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102: 2863-2867, 2006
Template and target information: (S)-propranolol, propranolol
Author keywords: molecular imprinting, Supercritical carbon dioxide, propranolol

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