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Reference type: Journal
Authors: Guo HS, He XW, Zhou J, Liang H
Article Title: Characteristics of molecular recognition of norfloxacin template polymer.
Publication date: 2001
Journal: Chinese Journal of Analytical Chemistry
Volume: 29
Issue: (2)
Page numbers: 128-132.
Alternative URL: http://en.cnki.com.cn/Article_en/CJFDTotal-FXHX200102001.htm

Abstract: A molecular template synthetic polymer highly selective for norfloxacinum was prepared by a molecular imprinting technique. The selective binding characteristics of the template polymer was evaluated by Scatchard analysis. The multiple-sites binding model was used to calculate the maximum number of binding sites, and the dissociation constant. The results showed that the template polymer using methacrylic acid (MAA) as functional monomer could form two kinds of binding sites. The dissociation constants were estimated to be K-d1 = 2.9 x 10(-5) mol/L and K- d2 = 3.2 x 10(-3) mol/L. The selective binding experiment for substrates indicated that the polymer gave much higher affinity and selectivity for norfloxacin than for acid pipemidic and cefalexin. It is possible to be a good adsorption and binding material in the selective enrichment and determination of trace norfloxacin in complex biosamples
Template and target information: norfloxacin


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