Abstract: A chemical sensor consists of two main components: molecular recognition and physical transduction. Integration of these recognition and transduction processes has elegantly been presently in biology by membrane ion channel. In our application, we have combined surface imprinting with proton sensitive nano-scale transducer: indium-tin oxide (ITO). We modified ITO electrode surface and developed imprinted structures on the surface for the molecular recognition. This integrated system was applied to differentiate electrochemically chiral amino acids. The sensors exhibited recognition properties towards one isomer of racemic N-carbobenzoxy aspartic acids (N-CBZ-Asp) without any pre-separation processes. Furthermore, rapid, specific recognition of methylphosphonic acid (MPA), a degradation product of nerve agent Sarin, and dipicolinic acid (DPA), a biomarker of endospores, were also achieved with the same method. The viability of MPA and DPA sensors in the presence of various interferences was investigated.
Template and target information: N-carbobenzoxy aspartic acids, N-CBZ-Asp, methylphosphonic acid, MPA, dipicolinic acid, DPA